McDonald S W, al Saffar R, Scothorne R J
Department of Anatomy, University of Glasgow, Scotland.
J Anat. 1991 Jun;176:35-44.
The cause of the variable immune response in the regional testicular lymph node of inbred Albino Swiss rats after vasectomy was investigated in two experiments. In the first, the ductus deferens was transected at its junction with the epididymis so that, in every case, sperm granulomas developed in the epididymis, from which lymph is known to drain invariably to the testicular node. In spite of this, not all testicular nodes showed histological signs of an immune response at 12 weeks after vasectomy. In the second experiment the contents of epididymal lymphatics were compared in vasectomised rats and sham-operated controls at intervals of up to 18 months after operation. Lymphatics in animals with an 'active' epididymal granuloma invariably contained numbers of macrophages and lymphocytes, thought to be involved in antigen transport, while those of controls contained none. It is concluded that variations in the lymphatic drainage of vasal granulomas were not primarily responsible for the variable lymph node response to vasectomy previously reported.
在两项实验中，对近交系白化瑞士大鼠输精管结扎后区域睾丸淋巴结中可变免疫反应的原因进行了研究。在第一项实验中，输精管在其与附睾的连接处被切断，这样在每种情况下，附睾中都会形成精子肉芽肿，已知淋巴液总是从附睾引流到睾丸淋巴结。尽管如此，并非所有睾丸淋巴结在输精管结扎后12周都表现出免疫反应的组织学迹象。在第二项实验中，在术后长达18个月的时间间隔内，比较了输精管结扎大鼠和假手术对照组附睾淋巴管的内容物。患有“活跃”附睾肉芽肿的动物的淋巴管中总是含有大量被认为参与抗原运输的巨噬细胞和淋巴细胞，而对照组的淋巴管中则没有。得出的结论是，输精管肉芽肿淋巴引流的变化并非先前报道的淋巴结对输精管结扎反应可变的主要原因。
