Waller M
Immunology. 1967 Dec;13(6):623-31.
A detailed study of the DEAE fractionated serum R. W. [anti-Gm(x)] has revealed differences in specificity between the 7S serum agglutinators of erythrocytes sensitized with anti-Rh antibodies digested with proteolytic enzymes and 19S rheumatoid factor monospecific for Gm(x). The serological reactivity and specificity of the serum agglutinators is determined by the enzymatic modification of the globulin molecules and is unrelated to the Gm type. On the other hand, the 19S rheumatoid factor [anti-Gm(x)] is reactive with undigested molecules or with those antibody molecules digested with proteolytic enzymes which leave the Fc piece intact. The 19S factor specificity is otherwise unrelated to digestion of the globulin molecule and rests solely on the intactness of the Gm site for which it is specific.
对用蛋白水解酶消化的抗Rh抗体致敏的红细胞的7S血清凝集素和对Gm(x)单特异性的19S类风湿因子之间的特异性差异进行了详细研究。血清凝集素的血清学反应性和特异性由球蛋白分子的酶促修饰决定，与Gm类型无关。另一方面，19S类风湿因子[抗Gm(x)]与未消化的分子或用蛋白水解酶消化但Fc片段完整的抗体分子反应。19S因子的特异性在其他方面与球蛋白分子的消化无关，仅取决于其特异性识别的Gm位点的完整性。
