1-苯丙氨酸氮芥对多发性骨髓瘤中抗球蛋白抗体的影响。

Waller M, Moon J H, Irby R, Toone E C

Clin Exp Immunol. 1971 Jan;8(1):91-100.

An immunochemical and serological study of a patient with rheumatoid arthritis who developed multiple myeloma and was treated with 1-phenylalanine mustard showed a striking difference in the effect of this drug on the rapidly dividing cells, as opposed to the resting plasma cells. The titres of anti-globulin antibodies such as the IgG serum agglutinators and the IgM rheumatoid factors were little altered although the IgG myeloma spike has disappeared following therapy. Fractionation of two different serum samples from 1966 and 1970 showed the IgG paraprotein to be serologically inactive for anti-globulin activity. This paraprotein was also characterized by producing only a single IgG precipitin line with horse anti-human whole serum antibody while the normal IgG globulins always showed a double line.

对一名患类风湿性关节炎且发展为多发性骨髓瘤并接受苯丙氨酸氮芥治疗的患者进行的免疫化学和血清学研究表明，与静止的浆细胞相比，该药物对快速分裂细胞的作用存在显著差异。尽管治疗后IgG骨髓瘤峰消失，但抗球蛋白抗体（如IgG血清凝集素和IgM类风湿因子）的滴度变化不大。对1966年和1970年的两份不同血清样本进行分级分离显示，IgG副蛋白在抗球蛋白活性方面血清学无活性。该副蛋白的特征还在于，与马抗人全血清抗体反应时仅产生一条IgG沉淀线，而正常IgG球蛋白总是显示两条线。