Barclay W R, Anacker R, Brehmer W, Ribi E
J Bacteriol. 1967 Nov;94(5):1736-45. doi: 10.1128/jb.94.5.1736-1745.1967.
Intravenous vaccination of mice with oil-treated mycobacterial cell walls resulted in a marked macrophage accumulation in the lungs and spleens of vaccinated animals. Injection of oil emulsion alone or of cell walls alone failed to elicit the macrophage response. Although a correlation existed between the magnitude of the macrophage response and the degree of immunity against aerosol challenge with H(37)Rv organisms, the findings presented here do not rule out the possibility that qualitative differences may be present in the macrophages of animals vaccinated against tuberculosis. The ability of oil-treated cell walls to elicit an immune response appeared to be a function of the physical association of cell wall fragments and the surface of oil droplets.
用经油处理的分枝杆菌细胞壁对小鼠进行静脉接种,导致接种动物的肺和脾中出现明显的巨噬细胞聚集。单独注射油乳剂或单独注射细胞壁均未能引发巨噬细胞反应。尽管巨噬细胞反应的强度与针对H(37)Rv菌株气溶胶攻击的免疫程度之间存在相关性,但此处呈现的研究结果并未排除接种抗结核疫苗的动物巨噬细胞中可能存在质量差异的可能性。经油处理的细胞壁引发免疫反应的能力似乎是细胞壁碎片与油滴表面物理结合的一种功能。