Seifart W
Arch Geschwulstforsch. 1979;49(3):264-71.
In colorectal carcinoma at the time of primary operation a much higher rate of occult micrometastases in the liver is to take in account as it is evident by the frequency of intraoperative found metastases (10--20%. Micrometastases likely can to need 3 to 8 years till they have increased so that the finally stage of generalization is to state. The survival rate of patients with colorectal carcinoma and hepatic metastases -- without therapy of metastases -- is 6 to 8 months and not differs from the survival rate of these patients whose primary tumor was inoperable by local reason. The today usual diagnostic procedures in the postoperative follow up control are able to detect liver metastases in most cases only in an inopportune stage for therapy. Probably the analysis of carcinoembryonic antigen is a progress in this question. The unique chance to block up or eliminate the frequently suspected micrometastases seems to be the general use of a post-operative adjuvant chemotherapy.
在结直肠癌初次手术时，肝脏隐匿性微转移的发生率要高得多，术中发现转移的频率（10%-20%）就证明了这一点。微转移可能需要3至8年才能增大到出现广泛转移的最终阶段。结直肠癌伴肝转移患者（不进行转移灶治疗）的生存率为6至8个月，与因局部原因导致原发肿瘤无法手术切除的患者生存率无差异。目前术后随访控制中常用的诊断程序，在大多数情况下只能在不利于治疗的阶段检测到肝转移。癌胚抗原分析可能是这个问题上的一个进展。阻止或消除经常被怀疑的微转移的唯一机会似乎是普遍采用术后辅助化疗。
