Knopf B, Wätzig V, Stelzner A
Arch Geschwulstforsch. 1979;49(4):299-304.
The levels of immunoglobulins (IgG, IgA and IgM) and of whole complement were measured in blood serum of 41 patients with malignant melanoma of clinical stage I to III after maximum tumour resection. In all three stages no differences to the normal could be obtained except for IgG demonstrating a rising tendency without statistic significance in patients of stage III. The level of whole complement was likewise normal in patients with the clinical stage I and II. A significant rise of the complement was observed in patients with clinical stage III in the last period of the disease. After one year of nonspecific active immunotherapy with BCG in patients of stages I and II no changes of immunoglobulins could be found. The whole complement showed a rising trend to the upper limit of the normal. The results were discussed in view of the present literature.
对41例临床I至III期恶性黑色素瘤患者在肿瘤最大程度切除后采集的血清进行了免疫球蛋白（IgG、IgA和IgM）及总补体水平的检测。在所有三个阶段中，除了III期患者的IgG呈上升趋势但无统计学意义外，与正常水平相比均无差异。临床I期和II期患者的总补体水平同样正常。在疾病后期的临床III期患者中观察到补体显著升高。对I期和II期患者进行卡介苗非特异性主动免疫治疗一年后，未发现免疫球蛋白有变化。总补体呈上升趋势，接近正常上限。结合当前文献对结果进行了讨论。
