Babakova S V, Kuznetsov V A, Gorodilova V V, Konradov A A, Chervonnaia L V
Vopr Onkol. 1988;34(3):314-8.
The study was concerned with the dynamics of correlations between IgA, IgM and IgG levels involved in pigmented neoplasm development in 154 cancer patients and 75 healthy subjects. The dynamics was found to represent stages of tumor development rather than changes in absolute indexes of serum immunoglobulin concentrations. The nature of changes in the structure of correlations suggested a possible switch from IgM to IgG and IgM to IgA secretion, i.e. disturbances in B-lymphocyte differentiation. Said changes were observed at a certain stage of melanoma progression, namely, during metastatic spreading.
该研究关注154名癌症患者和75名健康受试者中参与色素性肿瘤发展的IgA、IgM和IgG水平之间的相关性动态。发现这种动态代表肿瘤发展阶段，而非血清免疫球蛋白浓度绝对指标的变化。相关性结构变化的性质表明可能从IgM分泌转变为IgG分泌以及从IgM分泌转变为IgA分泌，即B淋巴细胞分化紊乱。上述变化在黑色素瘤进展的特定阶段观察到，即在转移扩散期间。
