诱导正常实验动物对流产布鲁氏菌内毒素产生致敏作用。
Induced sensitization of normal laboratory animals to Brucella abortus endotoxin.
作者信息
Freedman H H, Fox A E, Willis R S, Schwartz B S
出版信息
J Bacteriol. 1968 Feb;95(2):286-90. doi: 10.1128/jb.95.2.286-290.1968.
Abstract
A Boivin preparation of Brucella abortus, unlike common enterobacterial endotoxins, failed to depress water intake or increase numbers of hemolysin-producing spleen cells in mice, or to cause delayed inflammatory reactions in rabbit skin. Reactivity to the B. abortus endotoxin was found only in animals which were previously given the endotoxin with, but not necessarily in, complete Freund's adjuvant. Previous treatment with the endotoxin in saline or with only the adjuvant was ineffective. Sensitization appeared within 10 days and waned after 5 weeks. Passive sensitization was obtained with sensitized donor spleen cells but not with serum. Serum antibody titers did not correlate with the appearance and disappearance of sensitization.
摘要
流产布鲁氏菌的博伊文制剂与常见的肠道细菌内毒素不同，它不会降低小鼠的饮水量，也不会增加产生溶血素的脾细胞数量，或在兔皮中引起迟发性炎症反应。仅在先前用完全弗氏佐剂（不一定必须用）给予内毒素的动物中发现对流产布鲁氏菌内毒素有反应性。先前用盐水内毒素或仅用佐剂治疗无效。致敏在10天内出现，5周后减弱。用致敏供体脾细胞可获得被动致敏，但血清不能。血清抗体滴度与致敏的出现和消失无关。
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