Ruskin J, Remington J S
Science. 1968 Apr 5;160(3823):72-4. doi: 10.1126/science.160.3823.72.
Mice infected with the intracellular parasite Toxoplasma gondii for periods of as long as 7 months were resistant to challenge with numbers of Listeria monocytogenes and Salmonella typhimurium that were uniformly lethal to normal mice. This resistance did not appear to depend on the strain of toxoplasma employed or the route of inoculation of either toxoplasma or bacteria. Onset of immunity to listeria was demonstrable as early as 1 to 2 days after infection with toxoplasma. Resistance to toxoplasma was not demonstrable in mice immune to listeria. Interferon did not appear to be a mediator of the immunity observed in toxoplasma-infected mice.
感染细胞内寄生虫刚地弓形虫长达7个月的小鼠，对用一定数量的单核细胞增生李斯特菌和鼠伤寒沙门氏菌进行的攻击具有抵抗力，而这些数量的细菌对正常小鼠来说是一致致死的。这种抵抗力似乎不取决于所使用的弓形虫菌株，也不取决于弓形虫或细菌的接种途径。对李斯特菌的免疫最早在感染弓形虫后1至2天就可表现出来。对李斯特菌免疫的小鼠对弓形虫没有抵抗力。干扰素似乎不是在感染弓形虫的小鼠中观察到的免疫的介质。
