Ambuhl S, Williams V J, Senior W
Aust J Biol Sci. 1979 Apr;32(2):205-13. doi: 10.1071/bi9790205.
Caecectomized and sham-operated rats were fed a laboratory chow ad libitum and the effects of caecectomy on the digestibility of the food were studied. Compared with sham-operated controls, caecectomized rats showed a decrease in apparent digestibiltiy of organic matter from 77.8 to 73.0%, of crude protein from 83.0 to 79.4%, and of 'carbohydrate' from 74.6 to 69.0%. However, faecal water content increased from 41.6 to 54.8%. 51Cr-labelled EDTA was excreted faster in the faeces after caecectomy. The colon partly adapted to the loss of caecal mucosa by increased length and thus mucosal surface area. In a second concurrent experiment the effect of caecectomy on the apparent digestibility of food during food restriction was studied. Six caecectomized rats, comparable in all respects to those used in the first study, were fed the laboratory chow ad libitum for 3 weeks. They were then fed submaintenance amounts of food to achieve body weight losses of 40--50% and to maintain these low weights for 4 weeks. Finally, they were again fed ad libitum for 3 weeks. During the period of restriction the apparent digestibility of organic matter increased from 72.7 to 75.4%. This was largely due to the increased apparent digestibility of crude protein which rose from 78.4 to 81.9%. Digestibility coefficients returned to control values immediately upon refeeding ad libitum.
切除盲肠和假手术的大鼠随意进食实验室饲料，研究了盲肠切除对食物消化率的影响。与假手术对照组相比，切除盲肠的大鼠有机物表观消化率从77.8%降至73.0%，粗蛋白从83.0%降至79.4%，“碳水化合物”从74.6%降至69.0%。然而，粪便含水量从41.6%增加到54.8%。切除盲肠后，51Cr标记的EDTA在粪便中的排泄速度加快。结肠通过增加长度和黏膜表面积部分适应了盲肠黏膜的丧失。在第二个同期实验中，研究了食物限制期间盲肠切除对食物表观消化率的影响。六只切除盲肠的大鼠在各方面与第一项研究中使用的大鼠相当，随意进食实验室饲料3周。然后给它们喂食维持量以下的食物，使体重减轻40%至50%，并保持这些低体重4周。最后，再次让它们随意进食3周。在限制期内，有机物表观消化率从72.7%增加到75.4%。这主要是由于粗蛋白表观消化率的增加，从78.4%上升到81.9%。重新随意进食后，消化系数立即恢复到对照值。
