Horvath S M, Gliner J A, Matsen-Twisdale J A
Aviat Space Environ Med. 1979 Sep;50(9):901-5.
We examined changes in pulmonary function during resting exposure to concentrations of ozone at 0.75, 0.50, 0.25, and 0.00 parts/million (ppm), and determined the effect these exposures had on a subsequent maximum exercise test using filtered air. In order to determine if recovery of pulmonary function would be facilitated by increased ventilation due to maximum exercise, a control condition was conducted with subjects resting for a period equivalent to the maximum exercise condition. Eight males and five females participated in eight different conditions in order to answer these two questions. Resting 2-h exposure to 0.75 and 0.50 ppm ozone caused significant decrements in forced vital capacity of 10% and 5%, respectively. However, 0.00 and 0.25 ppm ozone induced no pulmonary decrement. None of the pollutant conditions reduced subsequent maximum exercise performance (ml O2.min-1.kg-1, heart rate, and total performance time). The pulmonary function responses after the maximum capacity test returned to pre-ozone values for the 0.50 ppm condition, but were still significantly decreased for the 0.75 ppm condition. The increased ventilatory exchanges from maximum exercise did not facilitate the return of pulmonary function. It appeared that increased ventilation during ozone exposure plays a significant role only in inducing pulmonary function decrement, but not in facilitating the return of pulmonary function to normal values.
我们研究了休息状态下暴露于浓度分别为0.75、0.50、0.25和0.00百万分率（ppm）的臭氧时肺功能的变化，并确定了这些暴露对随后使用过滤空气进行的最大运动测试的影响。为了确定最大运动引起的通气增加是否会促进肺功能的恢复，设置了一个对照条件，让受试者休息一段与最大运动条件相当的时间。八名男性和五名女性参与了八种不同的条件，以回答这两个问题。休息时暴露于0.75和0.50 ppm臭氧2小时分别导致用力肺活量显著下降10%和5%。然而，0.00和0.25 ppm的臭氧未引起肺功能下降。所有污染物条件均未降低随后的最大运动表现（毫升氧气·分钟-1·千克-1、心率和总运动时间）。最大运动测试后的肺功能反应在0.50 ppm条件下恢复到臭氧暴露前的值，但在0.75 ppm条件下仍显著下降。最大运动引起的通气增加并未促进肺功能的恢复。似乎臭氧暴露期间通气增加仅在引起肺功能下降方面起重要作用，而在促进肺功能恢复到正常水平方面不起作用。
