Lategola M T, Melton C E, Higgins E A
Aviat Space Environ Med. 1980 Mar;51(3):237-46.
Two studies were conducted to ascertain the lowest ozone concentration threshold for statistically significant adverse effects on cardiopulmonary function and symptoms in male and female surrogates of the flight attendant population. Both studies simulated in-flight environmental conditions at 1,829 m mean sea level (MSL) chamber altitude. The ozone exposures were 0.2 parts per million by volume (ppmv) for 4 h in the first study and 0.3 ppmv for 3 h in the second study. Each subject was similarly exposed to air only (no ozone) on another occasion. Treadmill exercise, equivalent to workloads of on-duty flight attendants, was performed at altitude. Cardiorespiratory measurements were made during ozone exposure, whereas spirometry and symptom assessments were made immediately before and after exposure. The ozone threshold for reversible adverse effects on symptoms and spirometry function was reached by a 3-h exposure to 0.3 ppmv. The data suggest a greater symptomatic sensitivity to ozone in females.
开展了两项研究，以确定对空乘人员的男性和女性替代者心肺功能及症状产生具有统计学意义的不利影响的最低臭氧浓度阈值。两项研究均在平均海平面（MSL）1829米的舱内高度模拟飞行中的环境条件。在第一项研究中，臭氧暴露浓度为0.2体积百万分比（ppmv），持续4小时；在第二项研究中，臭氧暴露浓度为0.3 ppmv，持续3小时。每个受试者在另一个时间段同样仅暴露于空气中（无臭氧）。在该高度进行相当于在职空乘人员工作量的跑步机运动。在臭氧暴露期间进行心肺测量，而在暴露前后立即进行肺活量测定和症状评估。暴露于0.3 ppmv的臭氧3小时达到了对症状和肺活量测定功能产生可逆性不利影响的臭氧阈值。数据表明女性对臭氧的症状敏感性更高。
