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Direct comparison of the N-acetyl-l-cysteine-sodium hydroxide and the trisodium phosphate digestion methods for the culture of mycobacteria.用于培养分枝杆菌的N-乙酰-L-半胱氨酸-氢氧化钠法与磷酸三钠消化法的直接比较
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本文引用的文献

1
THE IN VITRO REDUCTION IN VISCOSITY OF HUMAN TRACHEOBRONCHIAL SECRETIONS BY ACETYLCYSTEINE.乙酰半胱氨酸对人气管支气管分泌物的体外黏度降低作用
Am Rev Respir Dis. 1964 Nov;90:721-9. doi: 10.1164/arrd.1964.90.5.721.
2
COMMENTS ON THE USE OF THE NEW MUCOLYTIC AGENT, N-ACETYL-L-CYSTEINE, AS A SPUTUM DIGESTANT FOR THE ISOLATION OF MYCOBACTERIA.关于新型黏液溶解剂N-乙酰-L-半胱氨酸作为痰液消化剂用于分离分枝杆菌的评论
Am Rev Respir Dis. 1964 Feb;89:284-6. doi: 10.1164/arrd.1964.89.2.284.
3
Clinical evaluaton of a new mucolytic agent, acetyl-cysteine.一种新型黏液溶解剂——乙酰半胱氨酸的临床评估
J Thorac Cardiovasc Surg. 1962 Sep;44:330-43.
4
Sputum digestion and decontamination with N-acetyl-L-cysteine-sodium hydroxide for culture of mycobacteria.用N-乙酰-L-半胱氨酸-氢氧化钠进行痰液消化和净化以培养分枝杆菌。
Am Rev Respir Dis. 1963 May;87:775-9. doi: 10.1164/arrd.1963.87.5.775.

用于培养分枝杆菌的N-乙酰-L-半胱氨酸-氢氧化钠法与磷酸三钠消化法的直接比较

Direct comparison of the N-acetyl-l-cysteine-sodium hydroxide and the trisodium phosphate digestion methods for the culture of mycobacteria.

作者信息

Martin M E, Horton C L, Sheffner A L, Solomon J D

出版信息

Appl Microbiol. 1968 Mar;16(3):506-8. doi: 10.1128/am.16.3.506-508.1968.

DOI:10.1128/am.16.3.506-508.1968
PMID:4967759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC547449/
Abstract

Comparison of sputum digestion procedures utilizing acetylcysteine-sodium hydroxide (AC) and trisodium phosphate for the isolation and culture of mycobacteria indicated that the AC procedure provides faster growth, thus permitting the earlier detection of positives. Also, in untreated patients and those in whom treatment has been recently instituted, the number of positives was slightly larger with the use of the AC procedure. However, of greater interest was finding that the AC procedure provided a larger quantity of positive cultures with sputum from subjects who had been intensively treated with antimicrobials and other drugs. Contamination was higher with the AC procedure, but when the sputa were diluted 1:10 this interference due to contamination was decreased.

摘要

利用乙酰半胱氨酸 - 氢氧化钠（AC）和磷酸三钠进行痰液消化程序以分离和培养分枝杆菌的比较表明，AC程序能实现更快生长，从而可更早检测出阳性结果。此外，在未经治疗的患者以及最近开始治疗的患者中，使用AC程序检测出的阳性数量略多。然而，更值得关注的是，对于那些接受过抗菌药物和其他药物强化治疗的受试者的痰液，AC程序能提供更多阳性培养物。AC程序的污染率更高，但当痰液稀释1:10时，这种由污染导致的干扰会降低。