谷胱甘肽在大鼠肝小叶中的分布。
The distribution of glutathione in the rat liver lobule.
作者信息
Smith M T, Loveridge N, Wills E D, Chayen J
出版信息
Biochem J. 1979 Jul 15;182(1):103-8. doi: 10.1042/bj1820103.
Abstract
A quantitative cytochemical method was developed for measuring the GSH (reduced glutathione) content of hepatocytes in different regions of the rat liver lobule. Use of this method enabled us to show that GSH is not evenly distributed within the rat liver lobule. The hepatocytes located within 100 micrometer of the central vein contain much less GSH than do those in other regions of the rat liver lobule. We suggest that this partially explains the peculiar susceptibility of these cells to electrophilic attack by toxic metabolites formed via the microsomal cytochrome P-450 system.
摘要
已开发出一种定量细胞化学方法，用于测量大鼠肝小叶不同区域肝细胞中的谷胱甘肽（还原型谷胱甘肽）含量。使用该方法使我们能够表明，谷胱甘肽在大鼠肝小叶内分布不均。位于中央静脉100微米范围内的肝细胞所含谷胱甘肽比大鼠肝小叶其他区域的肝细胞少得多。我们认为，这部分解释了这些细胞对通过微粒体细胞色素P - 450系统形成的有毒代谢产物的亲电攻击具有特殊易感性的原因。
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