在急诊科进行的苯氧甲基青霉素、苯乙青霉素和林可霉素治疗葡萄球菌败血症的试验。
Trial of phenoxymethylpenicillin, phenethicillin, and lincomycin in treatment of staphylococcal sepsis in a casualty department.
作者信息
Price D J, O'Grady F W, Shooter R A, Weaver P C
出版信息
Br Med J. 1968 Aug 17;3(5615):407-9. doi: 10.1136/bmj.3.5615.407.
A comparative trial of phenoxymethylpenicillin (penicillin V), phenethicillin (Broxil), and lincomycin (Lincocin) against superficial staphylococcal infections seen in a casualty department showed no difference in the efficacy of the three agents, though half the staphylococci isolated were resistant to penicillin. Possible reasons include the fact that antibiotic treatment may not affect superficial staphylococcal infections, or that the organisms concerned may have been weak formers of penicillinase.Half the patients treated with lincomycin complained of diarrhoea and 5% of those treated with phenethicillin suffered from nausea.
一项针对急诊科常见浅表葡萄球菌感染，比较苯氧甲基青霉素（青霉素V）、苯乙青霉素（溴米索）和林可霉素（林肯霉素）疗效的试验表明，尽管分离出的葡萄球菌中有一半对青霉素耐药，但这三种药物的疗效并无差异。可能的原因包括抗生素治疗可能对浅表葡萄球菌感染没有影响，或者相关微生物可能是青霉素酶的微弱产生者。接受林可霉素治疗的患者中有一半抱怨腹泻，接受苯乙青霉素治疗的患者中有5%出现恶心症状。
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