Hoberman L J, Eigenbrodt E H, Kilman W J, Hughes L R, Norgaard R P, Fordtran J S
Am J Dig Dis. 1976 Jan;21(1):1-17. doi: 10.1007/BF01074133.
The clinical, radiologic, and histologic features of 16 patients hospitalized with clindamycin-associated colitis are presented. The findings are tabulated and compared to 33 cases reported in the literature. The majority of patients were caucasian females over 40 years of age. The clinical presentation varied from mild persistent diarrhea to acute surgical abdomen. Proctoscopic examination revealed nonspecific colitis in 9 and pseudomembranous colitis in 7 cases. No specific radiologic or histologic fingings for postanitbiotic colitis were found. Therapy was nonspecific and varied according to the severity of the clinical course. Clinically, there appeared to be some benefit from systemic steroid therapy. 4 of the 16 patients died. None of the recovered patients have had spontaneous relapses off medication during follow-up evaluation. The pathogenic mechanism for postantibiotic colitis secondary to clindamycin remains unknown and does not appear dose related. Clindamycin therapy should be limited to disorders with specific indications.
本文介绍了16例因克林霉素相关性结肠炎住院患者的临床、放射学和组织学特征。研究结果列表呈现，并与文献报道的33例病例进行比较。大多数患者为40岁以上的白人女性。临床表现从轻度持续性腹泻到急性急腹症不等。直肠镜检查发现9例为非特异性结肠炎，7例为假膜性结肠炎。未发现抗生素后结肠炎的特异性放射学或组织学表现。治疗方法不具特异性，根据临床病程的严重程度而异。临床上，全身使用类固醇治疗似乎有一定益处。16例患者中有4例死亡。在随访评估期间，所有康复患者停药后均未出现自发复发。克林霉素继发抗生素后结肠炎的发病机制尚不清楚，且似乎与剂量无关。克林霉素治疗应仅限于有特定指征的疾病。
