Vonk R J, Westra P, Houwertjes M C, Agoston S
Br J Anaesth. 1979 Aug;51(8):719-23. doi: 10.1093/bja/51.8.719.
The influence of bile salts on the duration of action of the steroidal non-depolarizing neuromuscular blocking agent ORG 6368 was investigated in cats. The intravenous administration of ORG 6368 (100 microgram/kg body wt) caused a maximum neuromuscular blockade of 71 +/- 6% with a duration of action of 3.4 +/- 0.1 min. However, intraportal administration of the same dose caused no significant neuromuscular blockade. Following an infusion of dehydrocholate 320 mumol, lasting for 8 min, the magnitude and the duration of action of the neuromuscular blockade produced by ORG 6368 were increased markedly. This effect of the bile salt is possibly a result of inhibition of the hepatic uptake of ORG 6368, thereby retarding its disappearance from the plasma and consequently prolonging the neuromuscular blockade. The neuromuscular blocking effect of intraportally administered gallamine (1 mg/kg body wt) was not influenced significantly by the infusion of dehydrocholate.
在猫身上研究了胆盐对甾体非去极化神经肌肉阻滞剂ORG 6368作用持续时间的影响。静脉注射ORG 6368（100微克/千克体重）可引起最大神经肌肉阻滞达71±6%，作用持续时间为3.4±0.1分钟。然而，经门静脉给予相同剂量未引起明显的神经肌肉阻滞。输注320微摩尔脱氢胆酸盐持续8分钟后，ORG 6368产生的神经肌肉阻滞的程度和作用持续时间显著增加。胆盐的这种作用可能是抑制ORG 6368肝脏摄取的结果，从而延缓其从血浆中消失，进而延长神经肌肉阻滞时间。经门静脉给予加拉明（1毫克/千克体重）的神经肌肉阻滞作用不受脱氢胆酸盐输注的显著影响。
