两种口服普鲁卡因胺缓释制剂的药代动力学比较。
A pharmacokinetic comparison of two sustained-release oral procainamide preparations.
作者信息
Hore P, Bones P, Rollinson T, Ikram H
出版信息
Br J Clin Pharmacol. 1979 Sep;8(3):267-71. doi: 10.1111/j.1365-2125.1979.tb01013.x.
1 The pharmacokinetics of two different sustained-release oral procainamide preparations were studied in ten hospital patients with normal blood ureas and no clinical evidence of heart failure. Each patient received either one or other preparation at 12 hourly intervals for four doses. Frequent blood sampling enabled close monitoring of blood levels. 2 Results showed that both preparations were essentially similar in their pharmacokinetics. Both effectively double the half-life of conventional oral procainamide to 6.5 h and are suitable as prophylactic preparations. One patient developed toxic levels, thought to be related to her metabolic status of being a very slow acetylator. To avoid toxicity pre-therapy assessment of a patient's cardiac and renal function and acetylator status is advised.
- 在10名血尿素正常且无心力衰竭临床证据的住院患者中，研究了两种不同的口服普鲁卡因胺缓释制剂的药代动力学。每位患者每隔12小时服用其中一种制剂，共服用4剂。频繁采血能够密切监测血药浓度。2. 结果表明，两种制剂的药代动力学基本相似。两者均有效地将传统口服普鲁卡因胺的半衰期延长一倍至6.5小时，适合作为预防性制剂。一名患者出现了中毒水平，认为这与她作为慢乙酰化者的代谢状态有关。建议在治疗前评估患者的心脏和肾功能以及乙酰化状态，以避免毒性反应。
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