Rapp R P, Schroeder H, DeLuca P P
Am J Hosp Pharm. 1976 Apr;33(4):352-6.
The suitability of a 5-mum stainless steel filter as an inline filter or a protective prefilter during simulated i.v. therapy was evaluated using flow rate measurements of two routinely used i.v. fluids and parenteral nutrition fluid. As an inline i.v. filter, the 5-mum stainless steel filter was capable of maintaining suitable flow rates. The addition of antibiotic additives decreased the flow rates slightly but not below the range required for i.v. therapy. Flow rate profiles, however, when compared to a 0.45-mum membrane filter suggest that antibiotic additives contain high numbers of particles in the less than 5-mum range. Consequently many of the particles, especially those in the less than 3-mum range will pass the 5-mum filter. As a protective prefilter, the 5-mum filter device in combination with a 0.45-mum membrane filter provided more uniform flow rates over longer periods of time when additives were employed. Using the aspiration device as a prefilter for adding antibiotics to the infusion fluid resulted in improved flow rates through a 0.45-mum membrane filter for lactated Ringer's containing cephalothin sodium, while for solutions containing ampicillin or oxytetracycline, prefilteration did not change the flow rate profiles.
使用两种常用静脉输液和肠外营养液的流速测量，评估了5微米不锈钢过滤器作为模拟静脉治疗期间的在线过滤器或保护性预过滤器的适用性。作为在线静脉过滤器，5微米不锈钢过滤器能够维持合适的流速。添加抗生素添加剂会使流速略有下降，但不会低于静脉治疗所需的范围。然而，与0.45微米膜过滤器相比，流速曲线表明抗生素添加剂含有大量小于5微米范围内的颗粒。因此，许多颗粒，尤其是小于3微米范围内的颗粒将通过5微米过滤器。作为保护性预过滤器，当使用添加剂时，5微米过滤装置与0.45微米膜过滤器相结合，在更长时间内提供了更均匀的流速。使用抽吸装置作为向输液中添加抗生素的预过滤器，对于含有头孢噻吩钠的乳酸林格氏液，通过0.45微米膜过滤器的流速得到了改善，而对于含有氨苄青霉素或土霉素的溶液，预过滤并没有改变流速曲线。
