DeLuca P P, Rapp R P, Bivins B, McKean H E, Griffen W O
Am J Hosp Pharm. 1975 Oct;32(10):1001-7.
The effect of final filtration on the incidence of infusion phlebitis was studied in a prospective, double-blind investigation involving 146 postoperative patients. The incidence of infusion phlebitis was found to be significantly reduced when an inline, 0.45-mum membrane filter was used. The greatest reduction of infusion phlebitis was in the filter groups receiving unbuffered solutions and no set change over the 72 hours of therapy. Buffering the infusion fluid or 24-hour change of the administration set did not have any effect on reducing the incidence of phlebitis. Antibiotic therapy appeared to have a slightly beneficial effect only when inline filters were employed. A significant rise in white blood cell count and an increase in sedimentation rate were observed in the patients receiving unfiltered fluids. It is recommended that inline final filters should be a part of routine intravenous therapy.
在一项涉及146例术后患者的前瞻性双盲研究中，研究了终端过滤对输注性静脉炎发生率的影响。当使用在线0.45微米膜过滤器时，发现输注性静脉炎的发生率显著降低。在接受无缓冲溶液且在72小时治疗期间未更换输液器的过滤器组中，输注性静脉炎的减少最为显著。对输液进行缓冲或24小时更换给药装置对降低静脉炎发生率没有任何作用。仅在使用在线过滤器时，抗生素治疗似乎有轻微的有益效果。在接受未过滤液体的患者中观察到白细胞计数显著升高和血沉加快。建议在线终端过滤器应成为常规静脉治疗的一部分。
