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Studies of the enzymatic deamination of ara-cytidine. V. inhibition in vitro and in vivo by tetrahydrouridine and other reduced pyrimidine nucleosides.

作者信息

Camiener G W

出版信息

Biochem Pharmacol. 1968 Sep;17(9):1981-91. doi: 10.1016/0006-2952(68)90114-7.

DOI:10.1016/0006-2952(68)90114-7
PMID:4972143
Abstract
摘要

相似文献

1
Studies of the enzymatic deamination of ara-cytidine. V. inhibition in vitro and in vivo by tetrahydrouridine and other reduced pyrimidine nucleosides.
Biochem Pharmacol. 1968 Sep;17(9):1981-91. doi: 10.1016/0006-2952(68)90114-7.
2
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Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides.
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The deamination of 5'-deoxycytidylic acid in normal adult rat liver and in Dunning hepatoma.正常成年大鼠肝脏和邓宁肝癌中5'-脱氧胞苷酸的脱氨作用。
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Pharmacology of combination chemotherapy of cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) or tetrahydrouridine (THU) against murine leukemia L1210/0 in tumor-bearing mice.阿糖胞苷（ara-C）与阿糖尿苷（ara-U）或四氢尿苷（THU）联合化疗对荷瘤小鼠体内鼠白血病L1210/0的药理作用。
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Chemotherapy. 1992;38(5):358-66. doi: 10.1159/000239026.

引用本文的文献

1
Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels.四氢尿苷通过细胞周期调控抑制细胞增殖，而与胞苷脱氨酶表达水平无关。
PLoS One. 2012;7(5):e37424. doi: 10.1371/journal.pone.0037424. Epub 2012 May 16.
2
Metabolism and mechanism of action of 5-fluorodeoxycytidine.5-氟脱氧胞苷的代谢与作用机制
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6419-23. doi: 10.1073/pnas.79.21.6419.
3
Incorporation of 5-substituted analogs of deoxycytidine into DNA of herpes simplex virus-infected or - transformed cells without deamination to the thymidine analog.
将脱氧胞苷的5-取代类似物掺入单纯疱疹病毒感染或转化细胞的DNA中，而不会脱氨基形成胸苷类似物。
Antimicrob Agents Chemother. 1983 Mar;23(3):465-76. doi: 10.1128/AAC.23.3.465.
4
Vaccinia virus: a selectable eukaryotic cloning and expression vector.痘苗病毒：一种可选择的真核克隆和表达载体。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7415-9. doi: 10.1073/pnas.79.23.7415.
5
Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity.脱氧胞苷在不丧失抗疱疹活性的情况下，选择性拮抗脱氧胞苷5-卤代类似物细胞毒性的能力。
Antimicrob Agents Chemother. 1982 Sep;22(3):431-41. doi: 10.1128/AAC.22.3.431.
6
Encapsidation and expression of the herpes thymidine kinase gene in polyoma virus.疱疹胸苷激酶基因在多瘤病毒中的衣壳化与表达
J Virol. 1982 May;42(2):691-9. doi: 10.1128/JVI.42.2.691-699.1982.
7
Tetrahydrouridine specifically facilitates deoxycytidine incorporation into herpes simplex virus DNA.四氢尿苷特异性地促进脱氧胞苷掺入单纯疱疹病毒DNA中。
J Virol. 1981 Mar;37(3):987-93. doi: 10.1128/JVI.37.3.987-993.1981.
8
Demonstration of a deoxycytidine kinase activity in extracts of Bacillus megaterium KM.巨大芽孢杆菌KM提取物中脱氧胞苷激酶活性的证明。
Appl Microbiol. 1973 Mar;25(3):506-8. doi: 10.1128/am.25.3.506-508.1973.
9
Purification and properties of cytidine deaminase from normal and leukemic granulocytes.正常及白血病粒细胞中胞苷脱氨酶的纯化及性质
J Clin Invest. 1974 Mar;53(3):922-31. doi: 10.1172/JCI107633.
10
Phosphorylation of 5-bromodeoxycytidine in cells infected with herpes simplex virus.感染单纯疱疹病毒的细胞中5-溴脱氧胞苷的磷酸化作用
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3788-92. doi: 10.1073/pnas.70.12.3788.