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通过冷沉淀法制备的血浆组分中的因子 VIII 和抗体水平。

Factor 8 and antibody levels in plasma fractions prepated by cryoprecipitation.

作者信息

Pollock A

出版信息

J Clin Pathol. 1968 Sep;21(5):635-7. doi: 10.1136/jcp.21.5.635.

DOI:10.1136/jcp.21.5.635
PMID:4972298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473878/
Abstract

Most of the antibody activity of plasma was found to remain in the supernatant fraction following the preparation of factor-VIII-rich cryoprecipitates. The low level of antibody remaining in these cryoprecipitates indicated that they could safely be used as a source of factor VIII for replacement therapy. Washing the cryoprecipitates farther reduced their antibody titres without materially affecting their factor VIII content.

摘要

在制备富含因子VIII的冷沉淀后，发现血浆中的大部分抗体活性仍保留在上清液部分。这些冷沉淀中残留的抗体水平较低，表明它们可安全地用作替代疗法的因子VIII来源。进一步洗涤冷沉淀可降低其抗体滴度，而对其因子VIII含量没有实质性影响。

相似文献

1
Factor 8 and antibody levels in plasma fractions prepated by cryoprecipitation.通过冷沉淀法制备的血浆组分中的因子 VIII 和抗体水平。
J Clin Pathol. 1968 Sep;21(5):635-7. doi: 10.1136/jcp.21.5.635.
2
Fractions rich in factor VIII.富含凝血因子VIII的组分。
Bibl Haematol. 1968;29:1122-6. doi: 10.1159/000384749.
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[Cryoprecipitates rich in factor VIII. In vitro and in vivo studies].[富含凝血因子VIII的冷沉淀。体外和体内研究]
Rev Fr Transfus. 1969 Dec;12(4):439-50. doi: 10.1016/s0035-2977(69)80110-0.
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Clearance of cryoprecipitated factor VIII in canine hemophilia A.犬血友病A中冷沉淀凝血因子VIII的清除率
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Cryoprecipitates and blood-groups.冷沉淀制剂与血型
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The preparation of a human plasma fraction by cryoprecipitation and its use in haemophilia.
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Z Gesamte Inn Med. 1974 Mar 15;29(6):236-40.
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[in vivo reappearance of injected cryoprecopitate (factor VIII concentrates) in patients with hemophilia A].
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本文引用的文献

1
PREVENTION OF RH-HAEMOLYTIC DISEASE: A THIRD REPORT.预防Rh溶血病：第三次报告
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Antepartum management of Rh hemolytic disease.Rh溶血病的产前管理。
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The factor-8 activity in fresh and stored plasma.新鲜血浆和储存血浆中的凝血因子Ⅷ活性。
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Production of high-potency concentrates of antihemophilic globulin in a closed-bag system.在密闭袋系统中生产高效抗血友病球蛋白浓缩物。
N Engl J Med. 1965 Dec 30;273(27):1443-7. doi: 10.1056/NEJM196512302732701.
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Treatment of haemophilia (factor-8 deficiency) with human antihaemophilic factor prepared by the cryoprecipitate process.
Lancet. 1967 Mar 4;1(7488):457-60. doi: 10.1016/s0140-6736(67)91087-2.
8
The effect of cryoprecipitate concentrate in patients with classical haemophilia.冷沉淀浓缩物对典型血友病患者的疗效。
Lancet. 1967 Jan 28;1(7483):191-2. doi: 10.1016/s0140-6736(67)91828-4.
9
Dose of anti-D gamma-globulin in prevention of Rh-haemolytic disease of the newborn.预防新生儿Rh溶血病的抗-D丙种球蛋白剂量
Br Med J. 1966 Jan 22;1(5481):213-4. doi: 10.1136/bmj.1.5481.213.