Schweitzer L
Biol Psychiatry. 1979 Oct;14(5):721-33.
Conjugate lateral eye movements (LEMs) have been used as a measure of contralateral frontal hemisphere activation when individuals carry out reflective tasks. In a previous study, schizophrenics were noted to produce significantly more R-LEMs than controls suggesting that they use the left hemisphere in general more often than controls when initiating thought. More specifically, schizophrenics initiated thought on spatial emotional material in their left hemisphere more often than normals. In an effort to replicate these findings, the present study contrasted a new sample of 13 schizophrenics first with the original schizophrenic sample, and then with 13 psychotic depressives, and the original controls. In addition, other group comparisons are reported. The data obtained replicate the original findings of increased R-LEM (i.e., increased left hemisphere activity) and the excessive processing of spatial and to a lesser extent emotional material in the left hemisphere of schizophrenics. Psychotic depressives were found to initiate reflective tasks more often in their right hemisphere than either schizophrenic or the original sample of normal controls. Significant group differences among schizophrenics, normal controls, and psychotically depressed patients were obtained. The data are consistent with emerging concepts of a left hemisphere locus of disturbance in schizophrenia and right hemisphere disturbances in affective disorders.
当个体执行反思任务时，共轭性眼球侧向运动（LEMs）已被用作对侧额叶半球激活的一种测量方法。在先前的一项研究中，发现精神分裂症患者产生的右向LEMs明显多于对照组，这表明他们在启动思维时，总体上比对照组更频繁地使用左半球。更具体地说，精神分裂症患者比正常人更频繁地在其左半球启动关于空间情感材料的思维。为了重复这些发现，本研究首先将13名精神分裂症患者的新样本与原始精神分裂症样本进行对比，然后与13名精神病性抑郁症患者以及原始对照组进行对比。此外，还报告了其他组间比较情况。所获得的数据重复了关于右向LEM增加（即左半球活动增加）以及精神分裂症患者左半球对空间材料过度加工且在较小程度上对情感材料过度加工的原始发现。发现精神病性抑郁症患者比精神分裂症患者或原始正常对照组样本更频繁地在其右半球启动反思任务。在精神分裂症患者、正常对照组和精神病性抑郁症患者之间获得了显著的组间差异。这些数据与精神分裂症中左半球功能障碍以及情感障碍中右半球功能障碍的新出现概念相一致。
