Schweitzer L, Becker E, Welsh H
Arch Gen Psychiatry. 1978 Aug;35(8):982-5. doi: 10.1001/archpsyc.1978.01770320076006.
Initial lateral eye movements (LEMs) have been shown to be associated with activation of the contralateral frontal lobes. Using LEM as a criterion measure of activation, schizophrenics were compared to normals with respect to the processing of four types of stimuli: verbal nonemotional (VNE), verbal emotional (VE), spatial nonemotional (SNE), and spatial emotional (SE). Our results indicate that schizophrenics initiate thought in their left hemisphere significantly more often than controls when one compares all test conditions and on VNE, VE, and SE material. Neither medication nor level of education had an appreciable effect on LEM in either group. However, sex was a significant variable; women irrespective of diagnosis consistently used the left hemisphere more often than men. The inappropriate initiation of thought on SE material as well as the overall increase in left hemisphere activity suggest left hemisphere disorder. This is consistent with other findings that suggest a left hemisphere locus of disturbance in schizophrenia.
最初的眼球横向运动（LEMs）已被证明与对侧额叶的激活有关。以LEM作为激活的标准测量指标，就四种类型的刺激（言语非情感性刺激VNE、言语情感性刺激VE、空间非情感性刺激SNE和空间情感性刺激SE）的处理情况，将精神分裂症患者与正常人进行了比较。我们的结果表明，当比较所有测试条件以及VNE、VE和SE材料时，精神分裂症患者在左半球启动思维的频率明显高于对照组。药物治疗和教育水平对两组的LEM均无明显影响。然而，性别是一个显著变量；无论诊断如何，女性使用左半球的频率始终高于男性。在SE材料上思维启动不当以及左半球活动的总体增加表明存在左半球功能紊乱。这与其他表明精神分裂症中干扰位于左半球的研究结果一致。
