大鼠中蝇蕈醇对吗啡镇痛作用的拮抗作用。
Muscimol antagonism of morphine analgesia in rats.
作者信息
Mantegazza P, Tammiso R, Vicentini L, Zambotti F, Zonta N
出版信息
Br J Pharmacol. 1979 Sep;67(1):103-7.
Abstract
1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia.
摘要
- 蝇蕈醇是一种γ-氨基丁酸（GABA）受体激动剂，脑室内注射时，可拮抗皮下或脑室内注射吗啡的镇痛作用。蝇蕈醇对吗啡镇痛的拮抗作用似乎呈线性关系。2. 这一发现支持了GABA能系统参与吗啡镇痛的观点。
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