[Possibility of modulating morphine analgesia against a background of activation of serotonin- and GABA-ergic processes].

The analgesic effect of morphine in conditions of serotonin- and GABA-ergic activation was studied in experiments on male albino rats. The serotonin re-uptake blockers fluoxetin and citalopram (10 and 20 mg/kg) did not exert clear analgesic effect or did not potentiate morphine action in doses of 5 and 10 mg/kg. The GABA agonist muscimol (0.5--2 mg/kg) did not influence the pain reaction structure and did not enhance morphine-induced analgesia. The role of serotonin- and GABA-ergic processes in realization of the analgesic action of morphine is discussed.