（+）-苯丙胺与氯丙嗪对大鼠脑干下部神经元的相互作用。
Interactions of (+)-amphetamine and chlorpromazine on neurones in the lower brain stem of the rat.
作者信息
Boakes R J, Bradley P B, Candy J M
出版信息
Br J Pharmacol. 1979 Oct;67(2):165-71. doi: 10.1111/j.1476-5381.1979.tb08662.x.
Abstract
1 The ability of chlorpromazine to antagonize the effects of iontophoretic application of (+)-amphetamine to single neurones in the medulla and lower pons of anaesthetized rats has been studied. 2 Chlorpromazine, administered systemically or iontophoretically, consistently and specifically antagonized the excitatory actions of (+)-amphetamine, but not those of noradrenaline on the same neurone. 3 It is concluded that chlorpromazine reduces the effect of (+)-amphetamine by a presynaptic mechanism. 4 (+)-Amphetamine did not mimic the prolonged inhibitory response of some neurones to noradrenaline but often excited these neurones and chlorpromazine blocked these excitatory responses to (+)-amphetamine.
摘要
- 研究了氯丙嗪拮抗离子导入（+）-苯丙胺对麻醉大鼠延髓和脑桥下部单个神经元作用的能力。2. 全身给药或离子导入氯丙嗪，能持续且特异性地拮抗（+）-苯丙胺的兴奋作用，但对同一神经元上去甲肾上腺素的兴奋作用无拮抗作用。3. 得出结论：氯丙嗪通过突触前机制降低（+）-苯丙胺的作用。4. （+）-苯丙胺不能模拟某些神经元对去甲肾上腺素的延长抑制反应，反而常使这些神经元兴奋，而氯丙嗪可阻断对（+）-苯丙胺的这些兴奋反应。
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