可传播水貂脑病病原体的物理和化学特性。
Physical and chemical properties of the transmissible mink encephalopathy agent.
作者信息
Marsh R F, Hanson R P
出版信息
J Virol. 1969 Feb;3(2):176-80. doi: 10.1128/JVI.3.2.176-180.1969.
Abstract
The size of the transmissible mink encephalopathy (TME) agent is estimated to be less than 50 nm on the basis of its passage through membrane filters. The agent is sensitive to ether, relatively resistant to 10% Formalin, resistant to ultraviolet irradiation, and susceptible to proteolytic digestion with Pronase. Attempts to extract an infectious nucleic acid fraction with hot phenol were unsuccessful. The results of these studies indicate that the TME agent has biochemical properties which are similar to those described for the transmissible agent of scrapie.
摘要
基于可传播水貂脑病（TME）病原体能通过膜滤器，其大小估计小于50纳米。该病原体对乙醚敏感，对10%福尔马林相对耐受，对紫外线照射耐受，且易被链霉蛋白酶进行蛋白水解消化。用热苯酚提取感染性核酸组分的尝试未成功。这些研究结果表明，TME病原体具有与羊瘙痒病可传播病原体所描述的生化特性相似的生化特性。
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