Hugo W B, Frier M
Appl Microbiol. 1969 Jan;17(1):118-27. doi: 10.1128/am.17.1.118-127.1969.
Dequalinium acetate is taken up rapidly by bacterial cells. Unlike the membrane-active drugs exemplified by cetrimide or chlorhexidine, its capacity for damaging the plasma membrane is low. The drug appears to penetrate quite rapidly into the cytoplasm where its effect seems to be exerted. A review of the evidence obtained in this study suggests that nucleic acid-containing components of the cell may be the prime target of this compound.
醋酸洗必泰能被细菌细胞迅速摄取。与以溴化十六烷基三甲铵或洗必泰为代表的膜活性药物不同，它损伤质膜的能力较低。该药物似乎能相当迅速地穿透进入细胞质，并在那里发挥作用。对本研究中获得的证据进行综述表明，细胞中含核酸的成分可能是该化合物的主要作用靶点。
