抗菌化合物醋酸洗必泰的作用方式。
Mode of action of the antibacterial compound dequalinium acetate.
作者信息
Hugo W B, Frier M
出版信息
Appl Microbiol. 1969 Jan;17(1):118-27. doi: 10.1128/am.17.1.118-127.1969.
Abstract
Dequalinium acetate is taken up rapidly by bacterial cells. Unlike the membrane-active drugs exemplified by cetrimide or chlorhexidine, its capacity for damaging the plasma membrane is low. The drug appears to penetrate quite rapidly into the cytoplasm where its effect seems to be exerted. A review of the evidence obtained in this study suggests that nucleic acid-containing components of the cell may be the prime target of this compound.
摘要
醋酸洗必泰能被细菌细胞迅速摄取。与以溴化十六烷基三甲铵或洗必泰为代表的膜活性药物不同，它损伤质膜的能力较低。该药物似乎能相当迅速地穿透进入细胞质，并在那里发挥作用。对本研究中获得的证据进行综述表明，细胞中含核酸的成分可能是该化合物的主要作用靶点。
相似文献
1
Mode of action of the antibacterial compound dequalinium acetate.抗菌化合物醋酸洗必泰的作用方式。
Appl Microbiol. 1969 Jan;17(1):118-27. doi: 10.1128/am.17.1.118-127.1969.
2
Studies on the mode of action of the streptogramin antibiotics.链阳性菌素类抗生素作用模式的研究。
J Gen Microbiol. 1966 Jan;42(1):93-106. doi: 10.1099/00221287-42-1-93.
3
Site of action of certain antibacterial heterocyclic quaternary ammonium compounds.某些抗菌杂环季铵化合物的作用部位
Appl Microbiol. 1965 Nov;13(6):956-66. doi: 10.1128/am.13.6.956-966.1965.
4
[The effect of neotelomycin on the cytoplasmic membranes of bacteria].
Antibiotiki. 1973 Nov;18(11):986-9.
5
[Antibacterial effect of chloramphenicol and nitrofurantoin under the effect of lysozyme].
Arch Hyg Bakteriol. 1968 Dec;152(5):477-81.
6
[Enzymatic modification of the effect of antibiotics].[抗生素作用的酶促修饰]
Arzneimittelforschung. 1969 Apr;19(4):674-6.
7
[Aflatoxin effect on bacteria].黄曲霉毒素对细菌的影响
Arch Hyg Bakteriol. 1970 Oct;154(2):143-7.
8
Effect of Prymnesium parvum toxin, cetyltrimethylammonium bromide and sodium dodecyl sulphate on bacteria.
J Gen Microbiol. 1970 Aug;62(3):363-70. doi: 10.1099/00221287-62-3-363.
9
[Obtaining protoplasts and spheroplasts in gram-positive cultures].[在革兰氏阳性培养物中获取原生质体和球状体]
Antibiotiki. 1969 Oct;14(10):880-3.
10
Comparison of the action of vantocil, cetrimide and chlorhexidine on Escherichia coli and its spheroplasts and the protoplasts of gram positive bacteria.万托西尔、西曲溴铵和洗必泰对大肠杆菌及其原生质球与革兰氏阳性菌原生质体作用的比较。
J Appl Bacteriol. 1968 Dec;31(4):448-61. doi: 10.1111/j.1365-2672.1968.tb00394.x.
引用本文的文献
1
Structure-Function Insights into Quinuclidine-3-One BisQACs: Synthesis, Modulation of Bacterial Resistance, Structure-Activity Relationship, and Biological Profiling.奎宁环-3-酮双季铵盐的结构-功能洞察：合成、细菌耐药性调控、构效关系及生物学特性分析
Pharmaceuticals (Basel). 2025 Aug 28;18(9):1286. doi: 10.3390/ph18091286.
2
A dual antibacterial action of soft quaternary ammonium compounds: bacteriostatic effects, membrane integrity, and reduced and toxicity.软质季铵化合物的双重抗菌作用：抑菌效果、膜完整性以及降低毒性。
RSC Adv. 2025 Jan 16;15(2):1490-1506. doi: 10.1039/d4ra07975b. eCollection 2025 Jan 9.
3
Synthesis of silane- and quaternary ammonium-bearing copolymers and application as a coating resin on cotton fabric.含硅烷和季铵的共聚物的合成及其作为棉织物涂层树脂的应用。
Turk J Chem. 2023 May 22;47(6):1320-1333. doi: 10.55730/1300-0527.3616. eCollection 2023.
4
Dequalinium Chloride for the Treatment of Vulvovaginal Infections: A Systematic Review and Meta-Analysis.盐酸地喹氯铵治疗外阴阴道感染的系统评价和荟萃分析。
J Low Genit Tract Dis. 2024 Jan 1;28(1):76-83. doi: 10.1097/LGT.0000000000000790. Epub 2023 Dec 7.
5
Bolaamphiphile Analogues of 12-bis-THA Cl Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens.12-双-THA-Cl 的两性嵌段类似物是具有不同作用机制的强效抗微生物治疗药物，可有效对抗细菌、分枝杆菌和真菌病原体。
mSphere. 2023 Feb 21;8(1):e0050822. doi: 10.1128/msphere.00508-22. Epub 2022 Dec 13.
6
Synthesis and Characterization of High Viscosity Cationic Poly(Proline-Epichlorohydrin) Composite Polymer with Antibacterial Functionalities.具有抗菌功能的高粘度阳离子聚（脯氨酸-环氧氯丙烷）复合聚合物的合成与表征
Polymers (Basel). 2022 Jul 8;14(14):2797. doi: 10.3390/polym14142797.
7
Dequalinium Chloride Effectively Disrupts Bacterial Vaginosis (BV) spp. Biofilms.氯化喹哑啉可有效破坏细菌性阴道病（BV）相关菌种的生物膜。
Pathogens. 2021 Feb 25;10(3):261. doi: 10.3390/pathogens10030261.
8
Increased Sensitivity of Amoeba-Grown Species to Disinfectants.变形虫培养的物种对消毒剂的敏感性增加。
Microorganisms. 2020 Aug 20;8(9):1260. doi: 10.3390/microorganisms8091260.
9
Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach.通过片段互补和药物重定位方法鉴定新型 Cdc7 激酶抑制剂作为以 Dbf4 相互作用为靶点的抗癌剂。
EBioMedicine. 2018 Oct;36:241-251. doi: 10.1016/j.ebiom.2018.09.030. Epub 2018 Oct 5.
10
Exploring the Antimicrobial Action of Quaternary Amines against .探索季铵盐类化合物对 … 的抗菌作用。
mBio. 2018 Feb 6;9(1):e02394-17. doi: 10.1128/mBio.02394-17.
本文引用的文献
1
BACTERIAL PROTOPLASTS INDUCED BY PENICILLIN.青霉素诱导的细菌原生质体
Proc Natl Acad Sci U S A. 1956 Sep;42(9):574-7. doi: 10.1073/pnas.42.9.574.
2
The bacterial surface. I. Effect of cetyl-trimethyl-ammonium bromide on the electrophoretic mobility of certain gram-positive bacteria.细菌表面。一、十六烷基三甲基溴化铵对某些革兰氏阳性菌电泳迁移率的影响。
Biochim Biophys Acta. 1950 Jun;5(3/4):463-71. doi: 10.1016/0006-3002(50)90192-2.
3
A NONSPECIFIC INCREASE IN PERMEABILITY IN ESCHERICHIA COLI PRODUCED BY EDTA.乙二胺四乙酸（EDTA）导致大肠杆菌通透性非特异性增加。
Proc Natl Acad Sci U S A. 1965 Apr;53(4):745-50. doi: 10.1073/pnas.53.4.745.
4
SOME ASPECTS OF THE MODE OF ACTION OF CHLORHEXIDINE.洗必泰的作用方式的某些方面。
J Pharm Pharmacol. 1964 Oct;16:655-62. doi: 10.1111/j.2042-7158.1964.tb07384.x.
5
Quantitative aspects of penicillin action on Escherichia coli in hypertonic medium.青霉素在高渗培养基中对大肠杆菌作用的定量研究
J Bacteriol. 1960 Oct;80(4):436-40. doi: 10.1128/jb.80.4.436-440.1960.
6
Lysis of gram-negative bacteria by lysozyme.溶菌酶对革兰氏阴性菌的裂解作用。
Biochim Biophys Acta. 1956 Oct;22(1):189-91. doi: 10.1016/0006-3002(56)90240-2.
7
Salts of decamethylene-bis-4-aminoquinaldinium (dequadin); a new antimicrobial agent.
J Pharm Pharmacol. 1956 Feb;8(2):110-9. doi: 10.1111/j.2042-7158.1956.tb12138.x.
8
The photometric determination of quaternary ammonium salts and of certain amines by compound formation with indicators. I. Quaternary ammonium salts.
J Pharm Pharmacol. 1954 Dec;6(12):971-85. doi: 10.1111/j.2042-7158.1954.tb11032.x.
9
The estimation of bactericidal activity from extinction time data.根据杀菌时间数据估算杀菌活性。
J Pharm Pharmacol. 1954 Sep;6(9):649-55. doi: 10.1111/j.2042-7158.1954.tb10999.x.
10
Site of action of polymyxin on Pseudomonas aeruginosa: antagonism by cations.多粘菌素对铜绿假单胞菌的作用位点：阳离子的拮抗作用。
J Gen Microbiol. 1954 Jun;10(3):491-9. doi: 10.1099/00221287-10-3-491.
Zotero 插件