Kelsen S G, Altose M D, Stanley N N, Levinson R S, Cherniack N S, Fishman A P
Am J Physiol. 1976 Mar;230(3):675-83. doi: 10.1152/ajplegacy.1976.230.3.675.
The response of respiratory motor neurons to graded elastic loading was assessed in anesthetized dogs by recording the electromyogram (EMG) from the diaphragm (ED) and the intercostal muscle (EIC). Elastic loads were applied for 1-20 breaths. The effects of changes in PCO2 on respiratory motor neuron output was assessed by applying loads during the course of CO2 rebreathing. On the first loaded breath, ED and EIC increased reflexly due chiefly to prolongation of inspiration. Vagotomy or vagal cooling to block the Hering-Breuer reflex eliminated the increase in ED and diminished the increase in EIC. During the second to fifth breath, the level of EMG activity was disproportionately high for the level of PCO2, suggesting an additional reflex component over and above the reflex activity present on the first loaded breath.
通过记录膈肌（ED）和肋间肌（EIC）的肌电图（EMG），在麻醉犬中评估呼吸运动神经元对分级弹性负荷的反应。弹性负荷施加1至20次呼吸。通过在二氧化碳再呼吸过程中施加负荷来评估PCO2变化对呼吸运动神经元输出的影响。在第一次负荷呼吸时，ED和EIC主要由于吸气延长而反射性增加。切断迷走神经或进行迷走神经冷却以阻断黑林 - 布雷尔反射可消除ED的增加并减少EIC的增加。在第二次至第五次呼吸期间，对于PCO2水平而言，EMG活动水平过高，这表明除了第一次负荷呼吸时存在的反射活动之外，还存在额外的反射成分。
