Cau P, Rougon-Rapuzzi G
Brain Res. 1979 Nov 16;177(2):265-71. doi: 10.1016/0006-8993(79)90777-7.
Rabbits immunized against vasopressin developed clinical signs of diabetes insipidus persisting for up to two months after the last boost. Ultrastructural and immunocytochemical studies of the neurohypophysis demonstrated autoimmune alterations: infiltration by immune cells and extracellular deposits of immunoglobulins. No alterations were observed in the hypothalamic nuclei synthesizing vasopressin nor in hormone-target cells of the kidney. Immunization against vasopressin may provide the first example of an autoimmune disease in the hypothalamo-neurohypophysial system.
用抗血管加压素免疫的兔子出现了尿崩症的临床症状，在最后一次加强免疫后持续长达两个月。对神经垂体的超微结构和免疫细胞化学研究显示出自身免疫性改变：免疫细胞浸润和免疫球蛋白的细胞外沉积。在合成血管加压素的下丘脑核以及肾脏的激素靶细胞中未观察到改变。抗血管加压素免疫可能提供了下丘脑 - 神经垂体系统自身免疫性疾病的首个实例。
