Denizot F, Golstein P
Immunology. 1982 May;46(1):89-95.
[3H'-thymidine incorporation above control levels was observed when normal mouse spleen cells were cultured with pituitary hormone-coupled albumins. Most striking was the observation of proliferation with self-hormone-coupled self-albumin, for instance vasopressin-coupled mouse serum albumin. The proliferating cells were not sensitive to anti-Thy 1 antiserum plus complement and were present in nude mouse spleens. Proliferation was accompanied with the appearance of antibody-forming cells against an irrelevant antigen (sheep red blood cells). These results strongly suggest polyclonal induction of B-cell proliferation/differentiation by self-hormone-coupled self-albumin.
当正常小鼠脾细胞与垂体激素偶联白蛋白一起培养时，观察到[3H'-胸苷掺入高于对照水平。最引人注目的是观察到自身激素偶联自身白蛋白（例如血管加压素偶联小鼠血清白蛋白）导致的增殖。增殖细胞对抗Thy 1抗血清加补体不敏感，且存在于裸鼠脾脏中。增殖伴随着针对无关抗原（绵羊红细胞）的抗体形成细胞的出现。这些结果强烈提示自身激素偶联自身白蛋白可多克隆诱导B细胞增殖/分化。
