Brockman R P
Can J Physiol Pharmacol. 1979 Aug;57(8):848-52. doi: 10.1139/y79-129.
The effect of somatostatin (SRIF) on glucagon and insulin secretion was examined in fed and fasted sheep. This was related to changes in glucose production. Infusion of SRIF at 80 micrograms/h caused a marked reduction in plasma glucagon concentrations. However, the insulin response to SRIF infusion was not consistent; its concentrations decreased occasionally, but often did not change. The depression of glucagon was not associated with a significant reduction in blood glucose concentrations in either fed or fasted sheep, but was associated with a reduction in glucose production by 12--15%. The inhibitory effect of insulin on glucose production was not markedly increased by glucagon deficiency. Infusion of insulin at 1.17 U/h with SRIF decreased glucose production only an additional 10%. Thus, it appears that under basal conditions pancreatic hormonal influences on hepatic glucose production were relatively small in sheep. This implies that under normal conditions in sheep, substrate supply has a much greater impact on hepatic glucogenesis than do hormones.
在喂食和禁食的绵羊中研究了生长抑素（SRIF）对胰高血糖素和胰岛素分泌的影响。这与葡萄糖生成的变化有关。以80微克/小时的速度输注SRIF导致血浆胰高血糖素浓度显著降低。然而，胰岛素对SRIF输注的反应并不一致；其浓度偶尔会降低，但通常没有变化。胰高血糖素的降低与喂食或禁食绵羊的血糖浓度显著降低无关，但与葡萄糖生成减少12%至15%有关。胰高血糖素缺乏并未显著增强胰岛素对葡萄糖生成的抑制作用。与SRIF一起以1.17单位/小时的速度输注胰岛素仅使葡萄糖生成再减少10%。因此，在基础条件下，绵羊胰腺激素对肝脏葡萄糖生成的影响似乎相对较小。这意味着在绵羊的正常条件下，底物供应对肝脏糖异生的影响比激素大得多。
