长效生长抑素类似物奥曲肽对绵羊皱胃功能及胰岛素和胰高血糖素血浆水平的影响。
Effects of the long-acting somatostatin analogue octreotide on abomasal function and plasma level of insulin and glucagon in sheep.
作者信息
Holtenius K
机构信息
Department of Clinical Nutrition, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
出版信息
Acta Vet Scand. 1994;35(3):235-41. doi: 10.1186/BF03548328.
The effects of the long-acting somatostatin analogue octreotide were studied in sheep. Octreotide was given subcutaneously at a dose of 0.75 microgram/kg bodyweight and, as a control, 0.9% saline solution was injected in a change-over design. Octreotide inhibited abomasal acid secretion and retarded the turnover time of digesta through the abomasum. The plasma levels of insulin and glucagon decreased due to the octreotide injection, while the plasma glucose level was not affected. The effects of octreotide lasted for 3-4h. There were no significant effects of the saline injection. The effects of octreotide showed similarities with results from previous studies on monogastric species.
研究了长效生长抑素类似物奥曲肽对绵羊的影响。奥曲肽以0.75微克/千克体重的剂量皮下注射，作为对照，在交叉设计中注射0.9%的盐溶液。奥曲肽抑制皱胃酸分泌，并延缓食糜通过皱胃的周转时间。注射奥曲肽后，胰岛素和胰高血糖素的血浆水平下降，而血浆葡萄糖水平未受影响。奥曲肽的作用持续3 - 4小时。注射盐溶液没有显著影响。奥曲肽的作用与先前对单胃动物的研究结果相似。
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