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在乙二胺四乙酸（EDTA）存在的情况下，血清因子导致血小板凝集。

Agglutination of platelets by a serum factor in the presence of EDTA.

作者信息

Gowland E, Kay H E, Spillman J C, Williamson J R

出版信息

J Clin Pathol. 1969 Jul;22(4):460-4. doi: 10.1136/jcp.22.4.460.

DOI:10.1136/jcp.22.4.460
PMID:4978997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC474212/
Abstract

The platelets of a patient with reticulum-cell sarcoma were found to exhibit agglutination and cytopathic changes when her blood was treated with EDTA but not with other anticoagulants. Investigation showed that the phenomenon was caused by a serum factor that was probably an antibody.

摘要

当用乙二胺四乙酸（EDTA）处理一名网状细胞肉瘤患者的血液时，发现其血小板出现凝集和细胞病变改变，而用其他抗凝剂处理时则未出现这种情况。研究表明，该现象是由一种可能为抗体的血清因子引起的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/f44ef8b76f7f/jclinpath00381-0080-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/f481a2dafc83/jclinpath00381-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/73154c41788d/jclinpath00381-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/8d977bf86a66/jclinpath00381-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/f44ef8b76f7f/jclinpath00381-0080-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/f481a2dafc83/jclinpath00381-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/73154c41788d/jclinpath00381-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/8d977bf86a66/jclinpath00381-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bfc/474212/f44ef8b76f7f/jclinpath00381-0080-c.jpg

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J Clin Pathol. 1969 Jul;22(4):460-4. doi: 10.1136/jcp.22.4.460.
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Blood. 1954 Jun;9(6):602-8.
2
The blood platelet: electron microscopic studies.血小板：电子显微镜研究
Int Rev Cytol. 1964;17:99-148. doi: 10.1016/s0074-7696(08)60406-4.
假性血小板减少症及其他与血小板计数假性降低相关的情况。
Haematologica. 2025 Aug 1;110(8):1677-1692. doi: 10.3324/haematol.2024.286234. Epub 2025 Mar 27.
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Kanamycin treated-ethylenediamine tetraacetic acid-dependent pseudothrombocytopenia in blood specimen of cats.猫血液样本中，经卡那霉素处理的乙二胺四乙酸依赖性假性血小板减少症。
Open Vet J. 2024 May;14(5):1199-1205. doi: 10.5455/OVJ.2024.v14.i5.15. Epub 2024 May 31.
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Integration of an MC-80 Digital Image Analyzer With an Automated BC-6800Plus Hematology Analyzer Enables Accurate Platelet Counting in Samples With EDTA-Induced Pseudothrombocytopenia.MC-80 数字图像分析仪与自动化 BC-6800Plus 血液分析仪的集成可实现 EDTA 诱导假性血小板减少症样本中血小板的准确计数。
Ann Lab Med. 2024 Nov 1;44(6):478-486. doi: 10.3343/alm.2023.0460. Epub 2024 Apr 4.
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