组胺在可的松诱导的豚鼠胃酸分泌过多中可能发挥的作用。
The possible role of histamine in the coritsone induced gastric acid hypersecretion of the guinea-pig.
作者信息
Heisler S, Kovacs E M
出版信息
Br J Pharmacol. 1969 Mar;35(3):498-509. doi: 10.1111/j.1476-5381.1969.tb08291.x.
Abstract
- The effects of cortisone treatment combined with agents influencing histamine metabolism were studied on the free and total acid output in pylorus ligated guinea-pigs.2. It was found that reduction in the synthesis of histamine produced by the administration of alpha-methylDOPA significantly inhibited the acid response to cortisone.3. Enhancement of the oxidative deamination of histamine brought about by the administration of diamine oxidase or heparin inhibited cortisone induced acid hypersecretion significantly.4. Inhibition of the oxidative deamination of histamine by aminoguanidine and iproniazid resulted in a significant increase of the cortisone induced acid hypersecretory response.5. Inhibition of the methylation of histamine by chlorpromazine or 1,4-methylhistamine inhibited the cortisone induced hypersecretory response significantly.6. Studies with labelled histamine indicated that cortisone increases the sequestration of histamine to the stomach.
摘要
研究了可的松治疗联合影响组胺代谢的药物对幽门结扎豚鼠游离酸和总酸分泌量的影响。
发现给予α-甲基多巴导致组胺合成减少，显著抑制了对可的松的酸反应。
给予二胺氧化酶或肝素引起组胺氧化脱氨增强，显著抑制了可的松诱导的胃酸分泌过多。
氨基胍和异烟肼抑制组胺氧化脱氨，导致可的松诱导的胃酸分泌过多反应显著增加。
氯丙嗪或1,4-甲基组胺抑制组胺甲基化，显著抑制了可的松诱导的胃酸分泌过多反应。
用标记组胺进行的研究表明，可的松增加了组胺在胃中的潴留。
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