氯丙嗪和二乙胺基溴麦角酸对大鼠组胺诱导胃酸分泌的影响。
EFFECTS OF CHLORPROMAZINE AND BROMOLYSERGIC ACID DIETHYLAMIDE ON GASTRIC SECRETION OF ACID INDUCED BY HISTAMINE IN RATS.
作者信息
AMURE B O, GINSBURG M
出版信息
Br J Pharmacol Chemother. 1964 Jun;22(3):520-6. doi: 10.1111/j.1476-5381.1964.tb01706.x.
Abstract
In anaesthetized rats in which the lumen of the stomach was perfused with 0.001 to 0.00025 N-sodium hydroxide solution and the pH of effluent fluid was recorded continuously, intravenous administration of chlorpromazine caused transient inhibition of acid secretion. After acid secretion had returned to the control level the responses to histamine were greater than those before chlorpromazine was given. Aminoguanidine, iproniazid and bromolysergic acid diethylamide also potentiated the effect of histamine on acid secretion but the initial inhibition was absent. Indirect evidence from experiments in which mixtures of aminoguanidine with chlorpromazine or bromolysergic acid diethylamide and of iproniazid with chlorpromazine or bromolysergic acid diethylamide were given, suggests that chlorpromazine and bromolysergic acid diethylamide enhance responses to histamine by inhibition of imidazole-N-methyl transferase.
摘要
在麻醉大鼠中，用0.001至0.00025N氢氧化钠溶液灌注胃腔并连续记录流出液的pH值，静脉注射氯丙嗪会引起胃酸分泌的短暂抑制。在胃酸分泌恢复到对照水平后，对组胺的反应比给予氯丙嗪之前更大。氨基胍、异烟肼和麦角酰二乙胺也增强了组胺对胃酸分泌的作用，但没有最初的抑制作用。给予氨基胍与氯丙嗪或麦角酰二乙胺的混合物以及异烟肼与氯丙嗪或麦角酰二乙胺的混合物的实验间接证据表明，氯丙嗪和麦角酰二乙胺通过抑制咪唑-N-甲基转移酶增强对组胺的反应。
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