Bussolati G, Monga G
Cancer. 1979 Nov;44(5):1769-77. doi: 10.1002/1097-0142(197911)44:5<1769::aid-cncr2820440534>3.0.co;2-z.
A case of a highly invasive thyroid carcinoma, which occurred in a 68-year-old woman, was studied by light and electron microscopy, and histochemical and biochemical analysis. Light microscopical, histochemical, and biochemical features were consistent with a diagnosis of a calcitonin-producing, amyloid-rich medullary carcinoma; electron microscopical patterns, mainly the presence of lumina, microvilli, and extensively dilated cytoplasmic E.R., were reminiscent of the ultrastructural features of the follicular carcinoma. Electron-dense bodies interpreted as "secretory granules" were very scarce. This case appears very similar to the case recently presented by Valenta et al. and interpreted as a microfollicular carcinoma. The atypical features of our case of MCT seem to indicate that this tumor should be included in a group of atypical MCT; these should be kept separate from the typical (differentiated) ones on morphological, functional, and prognostic grounds.
对一名68岁女性发生的高侵袭性甲状腺癌病例进行了光镜、电镜检查以及组织化学和生化分析。光镜、组织化学和生化特征与产生降钙素、富含淀粉样蛋白的髓样癌诊断相符；电镜图像，主要是管腔、微绒毛和广泛扩张的细胞质内质网的存在，让人联想到滤泡癌的超微结构特征。被解释为“分泌颗粒”的电子致密体非常稀少。该病例与Valenta等人最近报道并解释为微滤泡癌的病例非常相似。我们的髓样癌病例的非典型特征似乎表明，这种肿瘤应归入非典型髓样癌组；基于形态学、功能和预后方面的原因，应将其与典型（分化型）髓样癌区分开来。
