Lax S F, Beham A, Kronberger-Schönecker D, Langsteger W, Denk H
Institute of Pathology, University of Graz School of Medicine, Austria.
Virchows Arch. 1994;424(4):441-7. doi: 10.1007/BF00190568.
We present three thyroid carcinomas displaying medullary and papillary components. In two cases the papillary component was characterized by typical papillae with a fibrovascular core; in one a follicular variant of papillary carcinoma was found. The papillary component was dominant in two and the medullary in one case. One tumour showed clear-cut borders between the two components, the others displayed an intermingled pattern. Both tumour components were seen in lymph node metastases with immunostaining with antibodies to calcitonin, chromogranin A, carcinoembryonic antigen, other neuroendocrine markers and thyroglobulin. At least two of our cases are true mixed carcinomas probably arising from a common stem cell.
我们展示了三例具有髓样和乳头状成分的甲状腺癌。其中两例的乳头状成分以具有纤维血管轴心的典型乳头为特征；另一例发现为乳头状癌的滤泡变体。两例中乳头状成分占主导，一例中髓样成分占主导。一个肿瘤的两种成分之间界限清晰，其他肿瘤则呈现混合模式。通过使用降钙素、嗜铬粒蛋白A、癌胚抗原、其他神经内分泌标志物和甲状腺球蛋白的抗体进行免疫染色，在淋巴结转移灶中均可见到两种肿瘤成分。我们的病例中至少有两例是真正的混合癌，可能起源于共同的干细胞。
