Kepes J J, Rubinstein L J, Eng L F
Cancer. 1979 Nov;44(5):1839-52. doi: 10.1002/1097-0142(197911)44:5<1839::aid-cncr2820440543>3.0.co;2-0.
Twelve cases of a distinctive form of supratentorial astrocytoma occurring in young subjects (ages 7 to 25) are reported. The tumors were superficial and involved the leptomeninges extensively. The tumor cells display marked pleomorphism, including bizarre giant cells and a number of mitotic figures, but no necrosis. Many contain large amounts of lipid in their cytoplasm and are surrounded by reticulin fibers, thus simulating a mesenchymal tumor. For these reasons, some examples of this tumor have been previously interpreted to represent meningocerebral fibrous xanthomas. Immunoperoxidase technique performed in nine of the twelve cases has, however, established the presence of glial fibrillary acidic protein in the tumor cells, which are therefore considered to be astrocytic. By electron microscopy many tumor cells are surrounded by basal laminae, accounting for the abundant reticulin network demonstrable in silver preparations. Since subpial astrocytes are known to be partly covered by a basal lamina, it is likely that they are the cells of origin for this neoplasm. In contrast to its pleomorphic cytology, the biological behavior of this tumor appears to be relatively favorable, and long survival times (up to 25 years) have been recorded in some cases. (These tumors are distinct from intracranial fibrous xanthomas of mesenchymal derivation. Cells of the latter are negative on GFAP stain.)
报告了12例发生于年轻患者（7至25岁）的一种特殊类型的幕上星形细胞瘤。肿瘤位于表浅部位，广泛累及软脑膜。肿瘤细胞表现出明显的多形性，包括奇异的巨细胞和许多有丝分裂象，但无坏死。许多肿瘤细胞的胞质内含有大量脂质，并被网状纤维所包绕，因此类似间叶组织肿瘤。由于这些原因，该肿瘤的一些病例以前被解释为脑膜脑纤维黄色瘤。然而，在12例中的9例进行的免疫过氧化物酶技术检测显示肿瘤细胞中存在胶质纤维酸性蛋白，因此认为这些细胞是星形细胞。通过电子显微镜观察，许多肿瘤细胞被基膜包绕，这解释了在银染色标本中可见的丰富网状纤维网络。由于已知软膜下星形细胞部分被基膜覆盖，因此它们很可能是这种肿瘤的起源细胞。与其多形性细胞学表现不同，该肿瘤的生物学行为似乎相对良好，一些病例记录到较长的生存时间（长达25年）。（这些肿瘤与间叶组织来源的颅内纤维黄色瘤不同。后者的细胞GFAP染色呈阴性。）
