O'Donnell J F, Brereton H D, Greco F A, Gralnick H R, Johnson R E
Cancer. 1979 Nov;44(5):1930-8. doi: 10.1002/1097-0142(197911)44:5<1930::aid-cncr2820440556>3.0.co;2-e.
Seven cases of acute nonlymphocytic leukemia (ANLL) and one case of a malignant myeloproliferative syndrome have been seen after extensive radiation therapy for non-Hodgkin's lymphoma or chronic lymphocytic leukemia. A myeloproliferative syndrome with abnormalities in granulocytic, erythrocytic, and thrombocytic cell lines was present in all patients and in seven patients preceded ANLL by 2--18 months. The median time to the development of ANLL after primary disease therapy was 61 months (33--98 range). The leukemia was extremely refractory to therapy and median survival after diagnosis of ANLL was two months (range 0--9 months). Leukemia was seen only in those patients who received multiple courses and multiple techniques of radiation therapy.
7例急性非淋巴细胞白血病（ANLL）和1例恶性骨髓增殖综合征患者在接受非霍奇金淋巴瘤或慢性淋巴细胞白血病的广泛放射治疗后出现。所有患者均存在粒细胞、红细胞和血小板细胞系异常的骨髓增殖综合征，其中7例患者在ANLL出现前2至18个月就已出现该综合征。原发性疾病治疗后发生ANLL的中位时间为61个月（范围33至98个月）。该白血病对治疗极难耐受，ANLL诊断后的中位生存期为2个月（范围0至9个月）。白血病仅出现在那些接受多疗程和多种放疗技术的患者中。
