Becker F F
Cancer Res. 1979 Dec;39(12):5177-8.
Although a single pulse of dimethylnitrosamine administered during the regenerative response of liver subsequent to 70% hepatectomy resulted in more primary hepatocellular carcinomas in treated livers than in controls, the response was not proportionate to the level of cell division. Further, the use of 55-g male Sprague-Dawley rats that displayed an extremely active regenerative response did not significantly shorten the lag period before the appearance of tumors. Of additional interest was the finding that the post-S period might be even more susceptible to dimethylnitrosamine than the S phase was. These results support the suggestion that many aspects of the interaction between carcinogens and dividing cells and the requirement for subsequent events for the development remain unclear.
虽然在70%肝切除术后肝脏再生反应期间给予单次二甲基亚硝胺脉冲，导致治疗组肝脏中的原发性肝细胞癌比对照组更多，但这种反应与细胞分裂水平不成比例。此外，使用表现出极其活跃再生反应的55克雄性斯普拉格-道利大鼠，并未显著缩短肿瘤出现前的潜伏期。另外一个有趣的发现是，S期之后的时期可能比S期对二甲基亚硝胺更敏感。这些结果支持了这样一种观点，即致癌物与分裂细胞之间相互作用的许多方面以及肿瘤发生后续事件的要求仍不清楚。
