Heitmann P, Espinoza J
Gut. 1969 Oct;10(10):848-51. doi: 10.1136/gut.10.10.848.
Intraluminal manometric studies performed on 12 patients with chronic Chagas disease and megacolon without clinical or radiological abnormalities of the oesophagus showed no alteration in oesophageal physiology under basal conditions when compared with a control group of 30 healthy subjects. Oesophageal peristalsis was unimpaired. Patients with chronic Chagas disease and megacolon differed from normals in their reaction to a small dose of a cholinergic drug. This agent induced an isolated but significant increase in resting pressure at the level of the oesophagogastric sphincter, accompanied in most cases by an increase in spontaneous activity but not by a change in resting pressure in the body of the oesophagus. This is interpreted as a subclinical expression of oesophageal pathology related to Chagas disease.
对12例慢性恰加斯病合并巨结肠且无食管临床或放射学异常的患者进行腔内测压研究,结果显示,与30名健康受试者组成的对照组相比,在基础条件下这些患者的食管生理功能无改变。食管蠕动未受损。慢性恰加斯病合并巨结肠的患者在对小剂量胆碱能药物的反应方面与正常人不同。该药物导致食管胃括约肌水平的静息压力单独但显著升高,多数情况下伴有自发活动增加,但食管体部的静息压力无变化。这被解释为与恰加斯病相关的食管病理的亚临床表现。