Meneghelli U G, Godoy R A, Oliveira R B, Santos J C, Dantas R O, Troncon L E
Digestion. 1983;27(3):152-8. doi: 10.1159/000198945.
In order to evaluate the effect of pentagastrin on the motor activity of the sigmoid and rectum in patients with Chagas' disease, manometric studies were performed on 22 chagasic patients, 11 without and 11 with megacolon, and 11 control subjects. Pentagastrin had a stimulating effect on the sigmoid and rectum in control subjects as well as in chagasic patients without megacolon. In chagasic patients with megacolon, pentagastrin had no effect on sigmoid or rectum motility, probably as a result of the intrinsic denervation known to occur in this disease. The findings suggest that the motor effect of pentagastrin on the human sigmoid and rectum depends on the myenteric nervous pathways.
为评估五肽胃泌素对恰加斯病患者乙状结肠和直肠运动活性的影响，对22例恰加斯病患者（11例无巨结肠，11例有巨结肠）及11例对照者进行了测压研究。五肽胃泌素对对照者以及无巨结肠的恰加斯病患者的乙状结肠和直肠有刺激作用。在有巨结肠的恰加斯病患者中，五肽胃泌素对乙状结肠或直肠的运动无影响，这可能是由于已知该病存在内在去神经支配的结果。这些发现提示，五肽胃泌素对人乙状结肠和直肠的运动作用取决于肌间神经通路。
