患有巨食管和巨结肠的恰加斯病患者下食管括约肌对五肽胃泌素的反应。
Lower oesophageal sphincter response to pentagastrin in chagasic patients with megaoesophagus and megacolon.
作者信息
Padovan W, Godoy R A, Dantas R O, Meneghelli U G, Oliveira R B, Troncon L E
出版信息
Gut. 1980 Feb;21(2):85-90. doi: 10.1136/gut.21.2.85.
Intraluminal manometric studies were performed in 14 chagasic patients with megaoesophagus, 10 chagasic patients with megacolon, and 15 control subjects. Basal lower oesophageal sphincter pressure was 20.27+/-1.16 mmHg (mean+/-SEM) in controls as compared wtih 15.16+/-1.53 mmHg in chagasics with megaoesophagus and 14.38+/-1.50 mmHg in chagasics with megacolon. Dose-response studies to intravenous pentagastrin showed that the chagasic patients exhibited a lower sensitivity to the stimulant than did the controls, as demonstrated by shifting of the dose-response curve to the right and higher individual values of the dose for half maximal contraction (D50). No difference was noted between the calculated maximal contraction (Vmax) of oesophageal sphincter of controls and chagasics. These data are compatible with the hypothesis of an interaction between pentagastrin and cholinergic nervous excitation on oesophageal sphincteric smooth muscle.
对14例患有巨食管症的恰加斯病患者、10例患有巨结肠症的恰加斯病患者以及15名对照受试者进行了腔内测压研究。对照组的基础下食管括约肌压力为20.27±1.16 mmHg（平均值±标准误），而患有巨食管症的恰加斯病患者为15.16±1.53 mmHg，患有巨结肠症的恰加斯病患者为14.38±1.50 mmHg。对静脉注射五肽胃泌素的剂量反应研究表明，恰加斯病患者对该刺激物的敏感性低于对照组，剂量反应曲线右移以及半数最大收缩剂量（D50）的个体值更高即证明了这一点。对照组和恰加斯病患者食管括约肌的计算最大收缩（Vmax）之间未发现差异。这些数据与五肽胃泌素和胆碱能神经兴奋对食管括约肌平滑肌的相互作用假说相符。
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