Mittal K R, Ingram D G
Immunology. 1969 Nov;17(5):677-84.
The bactericidal activity of normal rabbit serum and of rabbit serum containing immunoconglutinin was studied with three Gram-negative and two Gram-positive bacteria and a yeast. With all micro-organisms tested, the immunoconglutinin sera had significantly higher bactericidal activities than normal sera. Absorption of natural homologous antibodies from normal serum led to inactivation of the bactericidal activity while absorption of natural heterologous antibodies resulted in a marked decrease in bactericidal activity. Similar absorptions of immunoconglutinin serum were much less effective in reducing the bactericidal activity. It is suggested that natural antibody and immunoconglutinin, in the presence of complement, act synergistically to increase bactericidal activity. Both normal and immunoconglutinin sera that had complement destroyed or absorbed failed to show any bactericidal activity. Attempts to absorb immunoconglutinin without destroying complement activity were unsuccessful. The physiological role of immunoconglutinin in increasing the resistance of man and animals to infectious diseases is discussed.
用三种革兰氏阴性菌、两种革兰氏阳性菌和一种酵母研究了正常兔血清及含免疫粘连素的兔血清的杀菌活性。对于所有测试的微生物，含免疫粘连素的血清的杀菌活性显著高于正常血清。从正常血清中吸收天然同源抗体导致杀菌活性丧失，而吸收天然异源抗体则导致杀菌活性显著降低。对免疫粘连素血清进行类似的吸收在降低杀菌活性方面效果要小得多。提示在补体存在的情况下，天然抗体和免疫粘连素协同作用以增强杀菌活性。补体被破坏或吸收的正常血清和免疫粘连素血清均未显示任何杀菌活性。试图在不破坏补体活性的情况下吸收免疫粘连素未获成功。文中讨论了免疫粘连素在增强人和动物对传染病抵抗力方面的生理作用。
