Possanza G J, Stewart P B
Clin Exp Immunol. 1970 Feb;6(2):291-7.
Procarbazine, a new immunosuppressant, was active in inhibiting the lesions of experimental arthritis in rats. In comparison with anti-lymphocyte serum it was somewhat more effective in suppressing the secondary than the primary lesion of adjuvant-induced disease. The anti-inflammatory action of procarbazine could not be correlated exactly with its immunosuppressant effect. The dosage scheme which began 21 days before immunization and which had the greater effect on the immune response, did not have any greater anti-arthritic effect than the dosage scheme started on day 0. Anti-lymphocyte serum and procarbazine both produced a fall of approximately 75% in the absolute number of circulating lymphocytes, without any significant effect on other elements in the peripheral blood.
丙卡巴肼是一种新型免疫抑制剂，对抑制大鼠实验性关节炎病变具有活性。与抗淋巴细胞血清相比，它在抑制佐剂诱导疾病的继发性病变方面比原发性病变更有效。丙卡巴肼的抗炎作用与其免疫抑制作用并无确切关联。在免疫前21天开始的给药方案对免疫反应影响更大，但与在第0天开始的给药方案相比，其抗关节炎作用并无更大效果。抗淋巴细胞血清和丙卡巴肼均使循环淋巴细胞的绝对数量下降了约75%，对外周血中的其他成分无显著影响。
