大鼠体内免疫抑制剂与抗炎剂的比较
A comparison of immunosuppressive and anti-inflammatory agents in the rat.
作者信息
Currey H L
出版信息
Clin Exp Immunol. 1971 Dec;9(6):879-87.
The action of four anti-proliferative agents: azathioprine, chlorambucil, cyclophosphamide and methotrexate have been studied in the rat and compared with the actions of phenylbutazone, hydrocortisone and anti-lymphocyte serum. All the anti-proliferative drugs effectively inhibited adjuvant arthritis. Therapeutic/toxic ratios were most favourable with cyclophosphamide, least favourable with azathioprine. In somewhat higher doses than those needed to inhibit adjuvant arthritis, the anti-proliferative drugs suppressed both the primary antibody response to sheep erythrocytes and the tuberculin skin test, and reduced the inflammatory paw swelling 48 hr after an injection of Freund's complete adjuvant. Anti-lymphocyte serum produced effects very similar to the anti-proliferative agents, including the anti-inflammatory effect. The results suggest that the inhibition of delayed hypersensitivity responses to tuberculin in rats receiving cyclophosphamide may represent a predominantly anti-inflammatory, rather an immunosuppressive, effect.
已经在大鼠中研究了四种抗增殖剂（硫唑嘌呤、苯丁酸氮芥、环磷酰胺和甲氨蝶呤）的作用，并与保泰松、氢化可的松和抗淋巴细胞血清的作用进行了比较。所有抗增殖药物均有效抑制佐剂性关节炎。环磷酰胺的治疗/毒性比最有利，硫唑嘌呤的最不利。在比抑制佐剂性关节炎所需剂量稍高的剂量下，抗增殖药物抑制了对绵羊红细胞的初次抗体反应和结核菌素皮肤试验，并在注射弗氏完全佐剂48小时后减轻了炎症性爪肿胀。抗淋巴细胞血清产生的效果与抗增殖剂非常相似，包括抗炎作用。结果表明，接受环磷酰胺的大鼠对结核菌素迟发型超敏反应的抑制可能主要代表抗炎作用，而非免疫抑制作用。
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