Pines A, Raafat H, Siddiqui G M, Greenfield J S
Br Med J. 1970 Mar 14;1(5697):663-5. doi: 10.1136/bmj.1.5697.663.
Experience in treating 81 patients with severe bronchial infection with Pseudomonas aeruginosa is described. For those who were desperately ill high doses of intravenous carbenicillin (18g. or more daily) were successful, even when initial carbenicillin resistance was present. For those who were less desperately ill lower doses of carbenicillin together with high doses of gentamicin (given both intramuscularly and by aerosol) comprised the treatment of choice. Gentamicin alone or colistin gave little or no benefit and cannot be recommended.
本文描述了治疗81例严重支气管铜绿假单胞菌感染患者的经验。对于病情危急的患者，即使最初存在羧苄西林耐药，大剂量静脉注射羧苄西林（每日18克或更多）也取得了成功。对于病情不那么危急的患者，较低剂量的羧苄西林与高剂量庆大霉素（肌肉注射和气雾吸入）联合使用是首选治疗方法。单独使用庆大霉素或黏菌素几乎没有益处，不推荐使用。
