Yuce K, Van Rooyen C E
Can Med Assoc J. 1971 Nov;105(9):919-22.
The administration separately and sequentially of carbenicillin and gentamicin eradicated Ps. aeruginosa infections, during the period over which they were given, in all of 25 critically ill patients. Electron microscopy revealed differences in the action of these two antibiotics against Ps. aeruginosa in vitro. Culture studies showed synergism between them and destruction by gentamicin of the carbenicillin-induced long, filamentous form of the organism.
在25例重症患者中，羧苄青霉素和庆大霉素先后分别给药，在给药期间均根除了铜绿假单胞菌感染。电子显微镜显示这两种抗生素在体外对铜绿假单胞菌的作用存在差异。培养研究表明它们之间具有协同作用，并且庆大霉素可破坏羧苄青霉素诱导产生的该菌的长丝状形态。
